Development of GLP-1MK-801 To safely harness the weight-lowering properties of NMDA receptor antagonism, we developed a targeting approach based on the hypothesis that conjugation of MK-801 to a GLP-1 analogue through a chemically cleavable disulfide linker would enhance the therapeutic potential of NMDA receptor antagonism in appetite-regulating brain regions enriched for GLP-1 receptors, while mitigating the adverse effects related to the non-restricted actions of MK-801
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Managing these side effects is crucial for the medication to work well for weight loss and diabetes control
ACS Appl Mater Interfaces 14(1):6993
Laboratory research record on Glutathione [PMID: 2130591] PubMed laboratory record discussing Glutathione in a research context
Left atrial volume and E/e ratio are crucial parameters in HFpEF and their improvement with GLP1-RA, together with the reduction of inflammation markers, may explain the expected benefits of this class of drugs in patients affected by HFpEF
